guidelines for the housing of mice in scientific institutions

Although a strain is considered stable when backcrossed for 10 generations, original 129 genes that are too close to the mutated gene to be segregated by … The National Research Council (NRC) “Guide for the Care and Use of Laboratory Animals” (2011) provides recommended minimum housing space expectations for laboratory rats and mice (p.57). Forty-one percent of institutions reported housing 0-20% of their mice under conventional conditions. The need for genotyping leads to the requirement to identify very young mice, thus creating specific problems (...) Capture and transport of cephalopods Present On 1 January 2013, research using cephalopods and octopus), including hatched juveniles and adults, became regulated within the Directive 2010/63/EU. However, rats and mice are social animals; and individual housing constitutes a stressful situation. Delayed weaning (weaning at >21 days) requires prior IACUC approval. Phone: (734) 763-8028 This preview shows page 45 - 48 out of 83 pages. HOUSING AND CARE preprint issued by THE ROYAL SOCIETY 6 Carlton House Terrace, London SWlY SAG and UNIVERSITIES FEDERATION FOR ANIMAL WELFARE 8 Hamilton Close, South … Instead, the author would cite animal housing guidelines such as those made available by their own institutions or by the NIH. Download Links [www.animalethics.org.au] ... BibTeX @MISC{12guidelinesfor, author = {}, title = {GUIDELINES FOR THE HOUSING OF MICE IN SCIENTIFIC INSTITUTIONS}, year = {2012}} Share. To address the health and well-being of mice and rats by ensuring safe breeding practices and population densities. When possible (depending on the caging system used) individually housed mice should be provided housing that allows visual, auditory and olfactory contact with other mice. Follow housing densities for the type of caging used. See Guidelines for Documenting Scientific Justification for Exceeding Cage Densities for details on required data. Provision for rabbits to withdraw from others should be provided, and subdivision to facilitate cleaning and catching animals in pens is recommended. Appendix A of the Council of Europe (2009) in the Convention for the protection of vertebrate animals used for experimental and other scientific … 3 0 obj A.L Hargreaves. The keeping of experimental animals requires housing systems appropriate to the needs and behaviour of each species, as demanded by various supranational and national guidelines. 4 0 obj According to UK Home Office guidelines, the room temperature for mice should be 20–24°C (68–75°F) and kept as stable as possible . The CCAC guidelines: Mice provides information for investigators, animal care committees, facility manag- Generally, in light of mice being gregarious animals, it is recommended to avoid individual housing whenever possible. To minimize fighting, the following group-housing practices are followed for mice: Do not combine adult male mice (older than 5 weeks). These rodents are social species and should be housed together, unless scientifically justified for individual housing. The NC3Rs have led a data crowdsourcing project, which estimated the prevalence of aggression in UK facilities as approximately 15 in every 1,000 mice. Current guidelines recommend housing mice in social groups as they are highly social animals, however, aggression and fighting can occur between group-housed males leading to injuries and potentially death. Wean pups by 21 days of age in either breeding scheme. GUIDELINES FOR RATS AND MICE . The design of animal housing should facilitate well being of the animals, meet research requirements, minimise experimental variables, and isolate the animals from wide variations in temperature and humidity and from vibration and sources of loud noise. <>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 612 792] /Contents 4 0 R/Group<>/Tabs/S/StructParents 0>> CCAC guidelines: Mice 1 PREFACE The Canadian Council on Animal Care (CCAC) is the national peer-review organization responsible for setting and maintaining standards for the ethics and care of animals in science throughout Canada. Guidelines for Transgenic Research. An exception to a Policy must be described and justified in the Animal Protocol and approved by the full IACUC at a convened monthly meeting. Guidelines for Housing Capacity. The authors concluded that housing mice at twice Guide-recommended densities has no deleterious impact on any of the parameters assessed. If post-partum estrus is used in "standard" mouse cages, the first litter must be weaned by 21 days of age to prevent the presence of two litters in a cage, i.e. No. … It is questionable whether conventional housing systems for rodents such as mice, rats and guinea-pigs meet this demand. Purpose. The primary objective of this code is to establish minimum standards and promote recommendations for the housing and care of … Mild to moderate wounds (those involving minimal damage to the epidermis) necessitates consultation with ULAM veterinary personnel for determination of appropriate therapy. Fax: (734) 936-3235 Institutional Animal Care and Use Committee . Ann Arbor, MI 48109 The Code of Practice for Housing and Care of Laboratory Mice, Rats, Guinea Pigs and Rabbits applies throughout Victoria. 412 Victor Vaughan Modifications of cages for mice usually consist of providing material for nest building and structures which can serve as hiding places and/or for climbing. )و�z�Ҡ�lcc�։7�޵����k�%� PP$rT��k�aK6m�B�B9&MV�����Z8�oWָ.�)^�>wjAВLt�ܵ�+:Rt {C1%�9p. Abstract. Whilst we appreciate the efforts made by individuals to improve the living conditions of those animals unfortunate enough to be used in research, AAHR feels it would be inappropriate to comment on a system that we consider to be scientifically flawed and are fundamentally opposed to. the draft guidelines for the housing of mice in scientific institutions. Code of practice for the housing and care of. Ann Arbor, MI 48109 2, 6, 9, 20, 24 It has also been shown to undergo extraintestinal replication as well. <> is recommended for principles of rabbit pen design. Effect of the Extract on the Intestinal Transit of Charcoal Meal in Mice. Code of Practice for the Housing and Care of Laboratory Mice Rats Guinea Pigs. 14 - 1 March 1999 Guidelines for the Care and Housing of Dogs in Scientific Institutions Animal Welfare Unit, NSW Agriculture, Locked Bag 21, Orange NSW 2800 Ph (02) 6391 3682 Fax (02) 6391 3570 or Sydney Office Ph (02) 9264 9533 Fax (02) 9264 9632 3 1. Limiting breeding cage occupancy reduces the incidence of morbidity and mortality due to overcrowding. Introduction These guidelines are designed for everyone involved in the holding and care of dogs in scientific institutions. This is Part 3.2 of the Code of Practice for the Housing and Care of Laboratory Mice, Rats, Guinea Pigs and Rabbits. Guidelines for Transgenic Research. Investigators must submit a BUworks Internal Service Request (ISR) for per diems and for special service charges prior to placing animal orders. Code of Practice for the Housing and Care of Animals Bred, Supplied or Used for Scientific Purposes Contents 4.15 Specific requirements of breeding animals 79 Section 3, Chapter 2: Mice, rats, gerbils, hamsters and guinea pigs 80 1 Advice applicable to all rodents 80 1.1 Environmental conditions 80 1.2 Health 81 1.3 Housing, enrichment and care 81 Nursing mothers or breeding pairs are kept in a quiet cage or tub with no wire floor. Unit for Laboratory Animal Medicine (ULAM) cage ("standard" rat cage). 2005 ) extended this study design with other mouse strains (young adult male and female BALB/cJ, NOD/LtJ, and FVB/NJ mice) to evaluate optimal housing densities. Housing of Social Species (Policy) Policy: The IACUC has provided a set of guidance documents (Policies, Guidelines, and Informational Sheets) for use when planning animal procedures at the University of Iowa. Find the maximum number of rats and mice that can be house in each cage in the Rodent Cage Capacity Policy. Enclosures designed to cause minimum disturbance to the animals. The 'Guidelines for the Housing of Rabbits in Scientific Institutions ' (see Section 4.) Follow procedures outlined in. • If scientifically justified in an approved IACUC protocol, mice may be individually housed in specific situations outlined in the IACUC protocol. Basic requirements for good rodent housing and husbandry are given in the table below. For infectious experiments, mice are transferred to a designated biosafety level 2 facility and usually are housed in static cages for the study duration. New arrival mice. if housed in standard #3 rat caging. the draft guidelines for the housing of mice in scientific institutions. (Enclosures should allow for a minimum floor area of 250cm2 for a single housed mouse, a minimum floor area of 500cm2 for two mice and ensuring a minimum floor area of 60cm2 per additional adult mouse when mice are housed in larger groups.) Whilst we appreciate the efforts made by individuals to improve the living conditions of those animals unfortunate enough to be used in research, AAHR feels it would be inappropriate to Therefore, it is unclear why housing many laboratory mice (>4), instead of one-or-two per cage, with the improper use/reporting of clustered-data statistics, abound in the literature. Guidelines for the Housing of Mice in Scientific Institutions Table of Contents RECOMMENDATIONS 4 1.0 GENERAL 20 1.1 INTRODUCTION 20 1.2 RESPONSIBILITIES OF INSTITUTIONS 21 1.3 RESPONSIBILITIES OF CHIEF INVESTIGATORS/ TEACHERS 21 1.4 THE AUSTRALIAN CODE OF PRACTICE FOR THE It establishes minimum standards for the housing and care of these animals under the Prevention of Cruelty to Animals Act 1986 (The Act) and … These guidelines have been written to assist faculty, staff, and students in performing vertebrate animal procedures in a humane manner and complying with pertinent regulatory requirements. With a physical land area of just over 700 square kilometers and a population of around 5.4 million people, this densely populated island has abundant tropical flora, parks, and g… Heterogeneity of the gut microbiome in mice: guidelines for optimizing experimental design Debby Laukens, ... the genetic history of mutant mice is often ambiguous when mice are shared between institutions (Sellers et al. For infectious experiments, mice are transferred to a designated biosafety level 2 facility and usually are … GUIDELINES FOR RATS AND MICE . Use a clean cage when combining males from different litters to prevent territorial behavior. Some colleagues have recommended housing intact male mice in groups of 3 to maintain stable dominance hierarchies and minimize aggression. animals for scientific purposes. endobj Pages 83. The NACLAR Guidelines set out the responsibilities of all the parties involved in the care and use of animals for scientific purposes, in accordance with widely accepted scientific, ethical and legal principles. ARRP Guideline 20: Guidelines for the Housing of Rats in Scientific Institutions Animal Welfare Branch, NSW Department of Primary Industries, Locked Bag 21, Orange NSW 2800. The keeping of experimental animals requires housing systems appropriate to the needs and behaviour of each species, as demanded by various supranational and national guidelines. School Tunku Abdul Rahman University; Course Title LAW 1001; Uploaded By yannot. Keyphrases. OLAW FAQ G10, Guide pp 6-7. Rats can be bred in the following conditions: Separate male before parturition if caging is <212 square inches, e.g. Canadian Council on Animal Care. The National Research Council (NRC) “Guide for the Care and Use of Laboratory Animals” (2011) provides recommended minimum housing space expectations for laboratory rats and mice (p.57). 28, 29 Using our strategy, we have been able to group-house as many as 10 castrated mice, in a large rat cage with enrichment materials, in harmonious social conditions. Typical husbandry conditions in our institution allow housing a maximum of 5 mice per cage and changing bedding every 2 wk within an SPF barrier facility. the Belgian Royal Decree of 6 April 2010 and European Directive 2010/63/EU on the protection of animals used for scientific purposes of 20 … Housing of Social Species (Policy) Policy: The IACUC has provided a set of guidance documents (Policies, Guidelines, and Informational Sheets) for use when planning animal procedures at the University of Iowa. in. Questions or concerns about the content of this document should be directed to the Unit for Laboratory Animal Medicine (ULAM) at (734) 764-0277 or ulam-questions@umich.edu. National Academy of Sciences is a private, nonprofit, self-perpetuating society of distinguished scholars engaged in scientific and engineering research, dedicated to the furtherance of science and technology and to their use for the general welfare.

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