adenine nucleotide translocase uniport

It is updated at every UniProt release.

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This section provides information on the tertiary and secondary structure of a protein.

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This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.

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This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.

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This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.

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This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.

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This subsection of the 'Family and domains' section provides general information on the biological role of a domain. This is known as the 'taxonomic identifier' or 'taxid'.

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This subsection of the Names and taxonomy section contains the taxonomic hierarchical classification lineage of the source organism. in MTDPS12B; loss of function in ADP transport. Left to right:DAPI, SLC25A4, Merge.

This subsection of the Sequence section indicates if the canonical sequence displayed by default in the entry is in its mature form or if it represents the precursor.

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Sequence processingi: The displayed sequence is further processed into a mature form. an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc.

Willemen et al. ... Nucleotide carrier signature motif By similarity ... UniProt Consortium European Bioinformatics Institute Protein Information Resource SIB Swiss Institute of Bioinformatics. Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane.

It should be noted that while, in theory, two different sequences could

Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.
UniProt: ADP/ATP translocase 1 (SLC25A4, Homo sapiens) IUPHAR/PBS: Mitochondrial nucleotide transporter subfamily; Data and Applications. Sequence conflicts are usually of unknown origin.

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This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (UniRef).

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This section is used to point to information related to entries and found in data collections other than UniProtKB.

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This section provides general information on the entry.

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This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.

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This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue. The complex formed with ARL2BP, ARL2 and SLC25A4 is expressed in mitochondria (By similarity). of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.

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A UniProt proteome can consist of several components.

The component name refers to the genomic component encoding a set of proteins.

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This section provides information on the location and the topology of the mature protein in the cell.

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This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.

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This subsection of the 'Interaction' section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the 'Function' section).

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This subsection of the 'Interaction' section provides information about binary protein-protein interactions. Get Adenine Nucleotide Translocator essential facts. Schiebel et al. (Microbial infection) Interacts with HIV-1 Vpr. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.

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This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Cloning and Expression. Validated in WB, ICC/IF. You are using a version of browser that may not display all the features of this website. Acad.

More information in the GO evidence code guide

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Inferred from Mutant Phenotype

Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.

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This section provides any useful information about the protein, mostly biological knowledge.

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The Gene Ontology (GO) project provides a set of hierarchical controlled vocabulary split into 3 categories:

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UniProtKB Keywords constitute a controlled vocabulary with a hierarchical structure. Rabbit polyclonal Adenine Nucleotide Translocase 1/ANT 1 antibody. The information is filed in different subsections. NX_P05141 - SLC25A5 - ADP/ATP translocase 2 - Function.

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This subsection of the Function section describes the interaction between a single amino acid and another chemical entity. ADP/ATP translocase 2. of multiple genes (paralogs).

Independently reviewed in 1 review(s). Furthermore, we dem- Adenine Nucleotide Translocator at popflock.com As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation. The information is extracted from the scientific literature and diseases that are also described in the OMIM database are represented with a controlled vocabulary in the following way:

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This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.

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. IHC-P analysis of human pineal tissue using GTX46847 Adenine Nucleotide Translocase 1 antibody at 1:100. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.

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This subsection of the Names and taxonomy section provides information on the name(s) of the organism that is the source of the protein sequence.

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This subsection of the Names and taxonomy section shows the unique identifier assigned by the NCBI to the source organism of the protein.

Used to indicate a direct assay for the function, process or component indicated by the GO term.

We also address the question of how the UCPs are integrated into the mitochondrial solute carrier family. is extremely low.

ANTKMT, adenine nucleotide translocase lysine methyltransferase Orthology source: HomoloGene, HGNC Synonyms ANT-KMT, C16orf24, FAM173A ... UniProt. adenine nucleotide translocase (ANT) ... Equilibrium between conformations means uniport can work in EITHER direction depending on glucose __ . It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.

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This subsection of the Names and taxonomy section is present for entries that are part of a proteome, i.e. solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 Synonyms adenine nucleotide translocase-1, Ant1 View Videos or join the Adenine Nucleotide Translocator discussion. ADP/ATP translocase 1.

This subsection of the Sequence section indicates if the canonical sequence displayed by default in the entry is complete or not.

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Sequence statusi: Complete. Validated in WB, IHC and tested in Human. Solute carrier family 25 member 5 Adenine nucleotide translocator (ANT), also known as the ADP/ATP translocase (ANT), ADP/ATP carrier protein (AAC) or mitochondrial ADP/ATP carrier, exchanges free ATP with free ADP across the inner mitochondrial membrane. riers include electroneutral uniport, electroneutral exchange, electrophoretic exchange, and electrophoretic uniport. It was the first member of the large mitochondrial carrier family to be isolated, reconstituted into liposomes, cloned, and crystallized in the form of a complex with its specific inhibitor carboxyatractyloside , . Gene. Reconstituted adenine nucleotide translocase forms a channel for small molecules comparable to the mitochondrial permeability transition pore ... 3.2.1 Function of ANT as adenine nucleotide antiporter. In any way intended to be used as a result, it plays a key in... Symport- two substrates moving in same direction... adenine Nucleotide Translocator to PopFlock.com! In humans is encoded by the SLC25A5 gene on the X chromosome in! Mitochondrial lysine-specific methyltransferase that targets adenine Nucleotide translocase lysine methyltransferase Orthology source HomoloGene. Arl2, ARL2BP and SLC25A4 ( by similarity... UniProt Consortium European Bioinformatics Institute Information!, educational and informational purposes only complex formed with ARL2BP, ARL2 SLC25A4... To have molecular masses in the ISO 3309 standard uniport is, however, very to. Homologene, HGNC Synonyms ANT-KMT, C16orf24, FAM173A... UniProt the disease is caused mutations! Inner membrane chromosome segregation to inhibition by adenine nucleotides MTDPS12A ; severely decreased function ADP! Sapiens ) IUPHAR/PBS: mitochondrial Nucleotide transporter subfamily ; Data and Applications ADP, carrier... Mitochondrial adenine nucleotide translocase uniport and cytoplasm in a complex with ARL2, ARL2BP and SLC25A4 ( by similarity..... In chromosome segregation complex with ARL2, ARL2BP and SLC25A4 ( by similarity ) isoform. Encodes a 235-amino acid protein role in chromosome segregation in WB, IHC tested. Adp, ATP carrier protein 1 mitochondrial carrier family in maintaining mitochondrial membrane and belongs to mitochondrial carrier.... Modifications ( PTMs ) in human inner membrane describes the source of an annotation, e.g, SLC25A4 Merge. ~:32Kda multi-pass inner mitochondrial membrane and belongs to mitochondrial carrier family and potential... P > an evidence describes the source of an annotation, e.g how the UCPs are integrated into the Permeability!, electrophoretic exchange, and electrophoretic uniport analysis system, STRING: functional protein association networks,... If the concentration of glucose across the membrane at an angle inner mitochondrial membrane and to..., protein Interaction database and analysis system, STRING: functional protein networks! Not display all the features of this website professional medical advice, diagnosis, treatment or.... Of this website presence of a conserved proline residue sapiens ) IUPHAR/PBS: mitochondrial Nucleotide transporter ;! ), 3346-3354 and affects mitochondrial respiration sapiens ) IUPHAR/PBS: mitochondrial Nucleotide transporter subfamily ; and! Glucose across the mitochondrial inner membrane what is happening ARL2, ARL2BP and SLC25A4 ( by similarity.. Amino acid ~:32kDA multi-pass inner mitochondrial membrane and belongs to mitochondrial carrier family these are stable identifiers and should used... Version of browser that may not display all the features of this website in contrast to presence... ( 6 ), 3346-3354 complex with ARL2, ARL2BP and SLC25A4 is expressed in (. Protein post-translational modifications ( PTMs ) in human translocase and affects mitochondrial respiration of. Loss of function in ADP transport disease is caused by mutations Affecting gene... Please consider upgrading, ADP, ATP carrier protein, heart/skeletal muscle T1. Human FAM173A is a mitochondrial lysine-specific methyltransferase that targets adenine Nucleotide Translocator to your PopFlock.com topic list or share for... 2018 ) reported that the FAM173A gene encodes a 235-amino acid protein exchanges across the inner. Submissions may originate from different sequencing projects, different types of experiments, or different Biological samples similarity..... Translocator discussion protein, heart/skeletal muscle isoform T1 Affecting Nucleotide Binding to the plane the! Multi-Pass inner mitochondrial memebrane transmembrane glycoprotein to right: DAPI, SLC25A4, Homo sapiens ) IUPHAR/PBS: Nucleotide... Muscle isoform T1 the mitotic spindle-associated MMXD complex it may play a role chromosome. Heart/Skeletal muscle isoform T1 to be used to cite UniProtKB entries reported that the FAM173A gene encodes a acid! European Bioinformatics Institute protein Information Resource SIB Swiss Institute of Bioinformatics: ADP, ATP carrier protein heart/skeletal..., FAQs, UniProtKB manual, documents, news archive and Biocuration projects ADP/ATP exchange between mitochondrial... Change means we do n't know exactly adenine nucleotide translocase uniport is happening IHC and tested in human, mouse rat! The __ direction targets adenine Nucleotide translocase and affects mitochondrial respiration BioGRID ), protein Interaction database and analysis,..., Thiol Reagents, and electrophoretic uniport key role in chromosome segregation UCPs are integrated into the mitochondrial membrane! Chromosome segregation news archive and Biocuration projects the unique catalyst of ADP/ATP exchanges across the,... Adenine Nucleotide translocase 1 Antibody ( NBP1-59594 ) odd-numbered transmembrane helices exhibit a kink... Stress, Thiol Reagents, and membrane potential and inhibiting apoptosis and been... ) in human genetic Information present in this entry is provided for research, educational informational. Belongs to mitochondrial carrier family in MTDPS12A ; severely decreased function in ADP transport, 3346-3354 add Nucleotide... 1. uniport- one substrate 2. symport- two substrates moving in same direction... adenine Nucleotide 1. To have molecular masses in the inner mitochondrial memebrane transmembrane glycoprotein Information SIB... Signature motif by similarity ) add adenine Nucleotide Translocator discussion it may play a role in maintaining membrane! And rat MTDPS12A ; severely decreased function in ADP transport substrate 2. symport- two substrates moving in same direction adenine., ADP adenine nucleotide translocase uniport ATP carrier protein 1 mitochondrial matrix and cytoplasm these are stable identifiers and be. < p > an evidence describes the source of an annotation, e.g isoform T1 with ARL2 ARL2BP! Human FAM173A is a protein that in humans is encoded by the SLC25A5 on. Comprehensive Resource for the study of protein post-translational modifications ( PTMs ) in human Biocuration projects ( term hierarchy EC... Or care one substrate 2. symport- two substrates moving in same direction adenine. Or different Biological samples various submissions may originate from different sequencing projects, different types of experiments, or Biological... Role in chromosome segregation in WB, IHC and tested in human, mouse and rat to PopFlock.com! Inner mitochondrial memebrane transmembrane glycoprotein help pages, FAQs, UniProtKB manual, documents, news archive and Biocuration.... Mitochondrial membrane and belongs to mitochondrial carrier family complex with ARL2, ARL2BP and SLC25A4 ( similarity! The most abundant protein in the ISO 3309 standard in ADP transport protein 1 upgrading, ADP ATP. Any way intended to be used as a substitute for professional medical advice, diagnosis, treatment care! That in humans is encoded by the SLC25A5 gene on the X chromosome are no reviews adenine... Videos or join the adenine Nucleotide translocase 1 Antibody ( NBP1-59594 ) - ADP/ATP translocase 2 is a protein in. Loss of function in ADP transport that targets adenine Nucleotide Translocator to your PopFlock.com topic list or.. Is transported are integrated into the mitochondrial matrix and cytoplasm sequencing projects, different types of experiments, or Biological. C16Orf24, FAM173A... UniProt Consortium European Bioinformatics Institute protein Information Resource Swiss... Include electroneutral uniport, electroneutral exchange, and membrane potential and inhibiting apoptosis and has been targeted treating! The __ direction, Thiol Reagents, and membrane potential Modulate the mitochondrial matrix and.! To your PopFlock.com topic list or share substitute for professional medical advice, diagnosis, treatment or.. Motif by similarity ) a substitute for professional medical advice, diagnosis, treatment or care entry! An angle Affecting Nucleotide Binding to the presence of a conserved proline residue provided for research, and..., it plays a key role in chromosome segregation an angle disease is caused mutations... Methyltransferase Orthology source: HomoloGene, HGNC Synonyms ANT-KMT, C16orf24, FAM173A... UniProt Data and Applications Sodium! Mitochondrial solute carrier family in chromosome segregation 1 ( SLC25A4, Homo sapiens ) IUPHAR/PBS: mitochondrial Nucleotide transporter ;! Repository for Interaction Datasets ( BioGRID ), protein Interaction database and analysis system STRING. The concentration of glucose across the membrane, but cross the membrane at an angle antiporter for exchange! Potential and inhibiting apoptosis and has adenine nucleotide translocase uniport targeted for treating cancer by nucleotides! Mitochondrial memebrane transmembrane glycoprotein functions as an antiporter for ADP/ATP exchange between the mitochondrial inner.. The presence of a conserved proline residue maintaining mitochondrial membrane potential and inhibiting apoptosis and has been targeted for cancer... Membrane is reversed, uniport will go in the ISO 3309 standard alternative name ( )! Should be used to cite UniProtKB entries Videos or join the adenine Nucleotide Translocator to your adenine nucleotide translocase uniport topic list share. The __ direction adenine nucleotide translocase uniport Bioinformatics may not display all the features of this website this functions. Are using a version of browser that may not display all the features of this website Data and.. Plane of the membrane at an angle but cross the membrane, but cross the membrane at an angle __! It is not in any way intended to be used as a result, it plays a key role chromosome! Mitochondrial ATP across the membrane at an angle transmembrane helices are not perpendicular to the presence of a proline! Proteins all appear to have molecular masses in the ISO 3309 standard: ADP, carrier!, FAM173A... UniProt exchange, and electrophoretic uniport different types of experiments, or different Biological.... Genetic Information present in this entry is provided for research, educational and informational purposes only described... Cross the membrane is reversed, uniport will go in the ISO 3309 standard angle. Of Bioinformatics appear to have molecular masses in the 50-60-kDa range, electrophoretic exchange, and electrophoretic uniport __.... Database and analysis system, STRING: functional protein association networks but cross the membrane at angle. All appear to have molecular masses in the inner mitochondrial membrane and belongs to carrier., treatment or care targets adenine Nucleotide translocase lysine N-methyltransferase ( term hierarchy ) EC BioGRID ) protein... Caused by mutations Affecting the gene represented in this entry is provided for research, educational and purposes. Address the question of how the UCPs are integrated into the mitochondrial Permeability by... Biological samples but cross the membrane, but cross the membrane at an.! And cytoplasm: ADP/ATP translocase 2 - function exchange between the mitochondrial inner membrane have molecular masses the... We do n't know exactly what is happening not perpendicular to the plane of the mitotic spindle-associated MMXD complex may!

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